Plasma concentration and urinary excretion of PEG 4000 after oral administration of a bowel lavage solution (MGV-5) contatining PEG 4000 in rats and dogs.
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منابع مشابه
EVALUATION OF PEG 4000 SOLUTION STABILITY IN DIFFERENT TEMPERATURES AND ENVIRONMENTAL CONDITIONS OVER THE TWELVE MONTHS
Background & Aims: Polyethylene glycol (PEG) solution is used as a laxative for the treatment of constipation in children. Due to the preparation of this solution as a compounding ingredient and solution instability as well as unavailability of the exact expiration date of compounding ingredients, it is necessary and important to investigate the stability of PEG solution. Materials & Methods: ...
متن کاملSolid Dispersions of Flufenamic Acid with Peg 4000 and Peg 6000
Non-steroidal anti-inflammatory drugs have an important impact in the actual medicinal therapy, having indications in covering the range from rheumatic inflammations to cardio-vascular, genito-urinary and stomatological diseases. Flufenamic acid is a nonsteroidal anti-inflammatory drug, from the class of fenamates. It exhibits poor aqueous solubility, accordingly the aim of this study was to en...
متن کاملActivity Coefficients of NaClO4 in (PEG 4000 + H2O) Mixtures at (288.15, 298.15 and 308.15) K
The cell potential of the cell containing two ion-selective electrodes (ISE), Na-ISE | NaClO4 (m), PEG 4000 (Y), H2O (100-Y) | ClO4-ISE has been measured at temperatures of (288.15, 298.15, and 308.15) K as a function of the weight percentage Y of PEG 4000 in a mixed solvent at a 1 Mpa and the standard state for measured activity coefficients will be ...
متن کاملLong-term safety of PEG 4000 in children with chronic functional constipation: A biochemical perspective
PURPOSE To evaluate the long-term safety of polyethylene glycol (PEG) 4000 in children with constipation, particularly the biochemical aspects of safety. METHODS Medical records were evaluated, and 100 children, who had been taking PEG 4000 for more than 6 months, and who had been under clinical and biochemical monitoring, were enrolled. Ages; 6.11±3.12 years, Duration of therapy; 16.93±7.02 ...
متن کاملAbsorption and excretion of metronidazole. I. Serum concentration and urinary excretion after oral administration.
Metronidazole (200 mg. three times daily for 7 days) cures approximately 90 per cent. of patients infested with Trichomonas vaginalis (Rodin, King, Nicol, and Barrow, 1960). This paper describes the first stage of an investigation designed to determine, in the first instance, the general absorption and excretion pattern of the drug and, secondly, the cause of failure in the remaining 10 per cen...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1989
ISSN: 0916-1139
DOI: 10.2133/dmpk.4.529